Fingolimod Hydrochloride is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. Fingolimod is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. Fingolimod is reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).
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Chemical Name | Fingolimod Hydrochloride |
Synonyms | 2-Amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol Hydrochloride; FTY720 Hydrochloride; |
CAS Number | 162359-56-0 |
Alternate CAS # | Free Base: 162359-55-9 |
Molecular Formula | C19H33NO2 • HCl |
Appearance | White to Off-White Solid |
Melting Point | >106°C (dec.) |
Molecular Weight | 307.48 + (36.46) |
Storage | -20°C Freezer |
Solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
Category | Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; |
Applications | Fingolimod Hydrochloride is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. Fingolimod is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. Fingolimod is reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively). |
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