Fingolimod hcl Cas 162359-56-0

Fingolimod, sold under the brand name Gilenya, is an immunomodulating medication, mostly used for treating multiple sclerosis (MS).Fingolimod is a sphingosine-1-phosphate receptor modulator, which sequesters lymphocytes in lymph nodes, preventing them from contributing to an autoimmune reaction. It has been reported to reduce the rate of relapses in relapsing-remitting multiple sclerosis by approximately one-half over a two-year period.

Fingolimod Hydrochloride is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. Fingolimod is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. Fingolimod is reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).

We have 99% high purity, adequate stock, customized packages

We have various shipping courier to guarantee the most stable and safest delivery

We have rich experience to solve potential customs issue for keep every promises

We have sent many orders to North America, East Europe,especially to Atlantic ,such as Australia,New Zealand

Chemical Name	Fingolimod Hydrochloride
Synonyms	2-Amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol Hydrochloride; FTY720 Hydrochloride;
CAS Number	162359-56-0
Alternate CAS #	Free Base: 162359-55-9
Molecular Formula	C19H33NO2 • HCl
Appearance	White to Off-White Solid
Melting Point	>106°C (dec.)
Molecular Weight	307.48 + (36.46)
Storage	-20°C Freezer
Solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
Category	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications	Fingolimod Hydrochloride is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. Fingolimod is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. Fingolimod is reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).