| Chemical Name | Fingolimod Hydrochloride |
| Synonyms | 2-Amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol Hydrochloride; FTY720 Hydrochloride; |
| CAS Number | 162359-56-0 |
| Alternate CAS # | Free Base: 162359-55-9 |
| Molecular Formula | C19H33NO2 • HCl |
| Appearance | White to Off-White Solid |
| Melting Point | >106°C (dec.) |
| Molecular Weight | 307.48 + (36.46) |
| Storage | -20°C Freezer |
| Solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| Category | Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; |
| Applications | Fingolimod Hydrochloride is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. Fingolimod is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. Fingolimod is reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively). |
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